Genesis Arc (originally called Super Meme Genesis, also known as the SMG Arc) is a science-fiction horror mystery adventure comedy-drama story arc and the first part of The SMG4 Cosmology Lore on SMG4's channel. It is the fifth major story arc in the SMG4 series after the Waluigi Arc, the Rapper Bob Arc, the Anime Arc and the YouTube Arc. It follows the mystery of the SMGs, their avatars, the memes, and Zero.

Seven months after the events of The YouTube Arc, Mario and SMG4 were attacked by a corrupted Morshu, and taken to the Internet Graveyard where SMG3 gave the place upgrade on social life well in a way. They found him, and he told them about the meme life cycle. He explained the meme appears on Earth when it gets popular on the internet, and gets happy when put to work. And naturally, the meme loses its relevance, dies and gets sent to the Internet Graveyard, where SMG3 looks after them until the meme becomes relevant again. However, a meme must be willing to transcend if they are looked after and happy, otherwise they remain in the realm and become corrupted if they stayed there for too long. SMG3 then sent SMG4 and Mario to deal with Morshu, by telling SMG4 to make him happy. Arriving back at the realm, where Morshu is getting more aggressive, SMG4 managed to make memes out of Morshu, finally making him happy, sending him to the graveyard. After the whole fiasco, SMG4 telephoned SMG3 to notify him, and asked how he took over the realm recently, in which SMG3 simply replied that he learned of the meme life cycle and took control from the meme gods.

One day, SMG4 became quite curious on how he got to where he is today after Mario asked what his past was and decided to seek help from SMG3. After talking to him, he runs to the Ancient Memes to know the truth and they showed them that they came from USB-shaped spacecrafts called Guardian Pods, SMG3's Guardian Pod was suppose to land in the Internet Graveyard, but a mysterious beam interfered with that plan as he was in 1 and 2s pod, while 4 landed in the mushroom kingdom, thus making the inhabitants to what they are today, and the only ones who can tame them are Mario and SMG4, and when SMG3 landed in the mushroom kingdom the 2 SMGs never saw eye to eye since then.

SMG4 wanted to celebrate 10 years of his channel, so he made a party to celebrate and invited friends, memes, and even enemies from the past and present. He even invited SMG3 and memes from the graveyard despite the warnings about the memes' corruption. After the party, SMG3 was about to take home his memes, only to find out that he had been denied access to the Internet Graveyard. The dead memes became corrupted, forcing the gang to fight but the gangs were eventually defeated, and SMG4, FX, X, SMG3 and Mario were abducted to an abandoned cathedral. At the cathedral, SMG4, SMG3 and Mario saw FM and X turned lifeless by extraterrestrial virus named SMG0, and found other lifeless Mario Recolors on the cathedral floor. Desperate, they managed to escape from the cathedral, but Mario was later captured by Zero. Trying to find any form of communication, SMG4 and SMG3 ventured into the Dark Web valley, later stealing live-stream equipment for any contact.

Meanwhile, the rest of the gang managed to escape the castle with the help of SMG1 and SMG2, who they were trying to get SMG4's attention to warn them about the appearances of Zero, a extraterrestrial virus that is dangerous to life and must be contained, and that they had escaped before until Zero followed them. SMG1 and SMG2 proceeded to tell the only way to defeat it by using a Guardian Pod, the USB that both SMG4 and SMG3 used to arrive in the Mushroom Kingdom. SMG4 realized that he threw his away by mistake, so he claimed that he didn't know where it was. SMG3 then suggested that they use his Guardian Pod, which was still stuck in the field it landed in. However, SMG4 and SMG3 were kidnapped again, and SMG2 advised them to keep their avatar safe. Back at the cathedral, Zero began to absorbed Mario's life energy, causing SMG4 and SMG3 to shriek in pain. Fortunately, the gang managed to rescue them, and SMG1 and SMG2, contained Zero once and for all. Zero, being contained, produced a black hole sucking SMG1 and SMG2, and Mario, their avatar, was freed.

After all that they rested on the rooftop of the castle and wondered why zero was trying to destroy avatars, and if there are other SMGs out there, the Guardian Pod containing Zero had its anti-virus subscription expired, causing a disturbance in the cathedral.

SMG4, Mario, Bob, Axol and Melony travelled to the Dark Web to find SMG4's Guardian Pod, undertaking a dangerous adventure. They later found the pod, discovered a library which has a corridor that lead to a central command. As Mario tampered the controls, it later revealed the story of the Guardian Pods, and how SMG3 was teleported away from his original destination, and found SMG1, SMG2 and Zero's pod crash landed in Corcovado in Rio de Janeiro, Brazil. Meanwhile, Bob strayed away from the crew after being enticed to see Butter Birdo, and unknowingly found SMG3's pod in Zero's cathedral. Unbeknownst to him when he was walking away, Zero emerged from the pod that has its antivirus subscription expired, following Bob behind.