1st phase (red eyes and pentience)

Can easy rush her with mass amounts of aleph employees with their high defence stats or you can you can play it safe with twilight ego set (apocalypse bird ego gear is is required for this method)

2nd phase (da capo and micicry

This phase is a jump from the previous phase best to use all aleph staff to deal with this phase the fastest her 3 movements to different facilities can be deadly and can end the run since she will throw da capo to the main department room that is select dealing damage that can a level 5 agent panic (100-130 white damage) and uses to micicry to deal massive red damage which can insta kill agents

Phase 3 (Smile and Justista)

Red mist will equip smile and justista and will perform medium to short ranged attacks to beat this phase you will require ranged aleph gear (sound of the star or pink best to have both)

Phase 4 (Twilight)

Getting to phase is no easy task and is the most hurtful phase she will target a random employee and sprint towards them at pretty much at the speed of mach 4.35 once reaching them she will perform a heavy attack if she doesnt reach them in time (movement reduction bullets can help slow her down by 50%) she will have reduced defences and be unable to attack best to have all employees attack her to have maxium damage

Some other tips have low staff to for reduced casualties and a higher day rank