kratom extract! - Recent data suggests that Ibuprofen and diclofenac can slightly increase the risk of heart problems if taken in high doses for a long time. Most users do not need to worry but many will be concerned. Does the pain relief outweigh the risks? One possible alternative is UC-II - a non-prescription chicken derived health supplement which a small trial has indicated are more effective in reducing pain than glucosamine and chondroitin.