1, Travel Restrictions:Choose the direction about the place you wanna go first in basic mod.Instead of going one way only (If that can be added into the game, It really needs a lot time to achieve it.)
2,Easy mod disabled:In harder mod. Some enemies could stop you won't let you get some rare supplies and equipment or the way to reduce difficulty of the game.
3,More possible endings: Like being killed,escaping from Olathe,being the part of the Olathe or even more crazy shits.
4,Battle Features:It is best to end certain battles sooner,or else it could be pretty long to get rid of it.Some battles will make the process later more difficult.Fight in a gang base is a really dumb act
It is also sometimes important to avoid fighting.
5,NPC requests:Some advantages can be take by completing requests from certain people, and even recruiting new party members.

6,A new play mode that was harder than pain mode:If you already beat the pain mode for so many times,it is could be necessary to have a even harder play mode.In this mode,you would better to avoid fighting and saving often.Enemies will be horribly strong,so strong that it's easy and common to beat you up really bad.